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Targeting the neurovascular unit for treatment of neurological disorders

Drug discovery for CNS disorders has been restricted by the inability for therapeutic agents to cross the blood-brain barrier (BBB). Moreover, current drugs aim to correct neuron cell signaling, thereby neglecting pathophysiological changes affecting other cell types of the neurovascular unit (NVU)....

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Bibliographic Details
Main Authors: VanGilder, Reyna L., Rosen, Charles L., Barr, Taura L., Huber, Jason D.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092634/
https://ncbi.nlm.nih.gov/pubmed/21172386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2010.12.004
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