Microarray Identifies Extensive Downregulation of Noncollagen Extracellular Matrix and Profibrotic Growth Factor Genes in Chronic Isolated Mitral Regurgitation in the Dog

BACKGROUND: The volume overload of isolated mitral regurgitation (MR) in the dog results in left ventricular (LV) dilatation and interstitial collagen loss. To better understand the mechanism of collagen loss we performed a gene array and overlaid regulated genes into Ingenuity Pathway Analysis (IPA...

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Autors principals: Zheng, Junying, Chen, Yuanwen, Pat, Betty, Dell’Italia, Louis A, Tillson, Michael, Dillon, A Ray, Powell, Pamela, Shi, Ke, Shah, Neil, Denney, Thomas, Husain, Ahsan, Dell’Italia, Louis J
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092370/
https://ncbi.nlm.nih.gov/pubmed/19349319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.826230
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