Analysis of Exonic Regions Involved in Nuclear Localization, Splicing Activity, and Dimerization of Muscleblind-like-1 Isoforms

Muscleblind-like-1 (MBNL1) is a splicing regulatory factor controlling the fetal-to-adult alternative splicing transitions during vertebrate muscle development. Its capture by nuclear CUG expansions is one major cause for type 1 myotonic dystrophy (DM1). Alternative splicing produces MBNL1 isoforms...

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Main Authors: Tran, Hélène, Gourrier, Nathalie, Lemercier-Neuillet, Camille, Dhaenens, Claire-Marie, Vautrin, Audrey, Fernandez-Gomez, Francisco José, Arandel, Ludovic, Carpentier, Céline, Obriot, Hélène, Eddarkaoui, Sabiha, Delattre, Lucie, Van Brussels, Edwige, Holt, Ian, Morris, Glenn E., Sablonnière, Bernard, Buée, Luc, Charlet-Berguerand, Nicolas, Schraen-Maschke, Susanna, Furling, Denis, Behm-Ansmant, Isabelle, Branlant, Christiane, Caillet-Boudin, Marie-Laure, Sergeant, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091249/
https://ncbi.nlm.nih.gov/pubmed/21454535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.194928
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