Oxygen Binding and Redox Properties of the Heme in Soluble Guanylate Cyclase: IMPLICATIONS FOR THE MECHANISM OF LIGAND DISCRIMINATION

Soluble guanylate cyclase is an NO-sensing hemoprotein that serves as a NO receptor in NO-mediated signaling pathways. It has been believed that this enzyme displays no measurable affinity for O(2), thereby enabling the selective NO sensing in aerobic environments. Despite the physiological signific...

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Bibliographic Details
Main Authors: Makino, Ryu, Park, Sam-yon, Obayashi, Eiji, Iizuka, Tetsutaro, Hori, Hiroshi, Shiro, Yoshitugu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3091176/
https://ncbi.nlm.nih.gov/pubmed/21385878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.177576
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