Discovery of a Potent and Efficacious Peptide Derivative for δ/μ Opioid Agonist/Neurokinin 1 Antagonist Activity with a 2′, 6′-Dimethyl-L-Tyrosine: In Vitro, In Vivo and NMR-Based Structural Studies

Multivalent ligands with delta/mu opioid agonist and NK1 antagonist activities have shown promising analgesic potency without detectable sign of toxicities, including motor skill impairment and opioid-induced tolerance. To improve their biological activities and metabolic stability, structural optim...

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Detalhes bibliográficos
Main Authors: Yamamoto, Takashi, Nair, Padma, Largent-Milnes, Tally M., Jacobsen, Neil E., Davis, Peg, Ma, Shouwu, Yamamura, Henry I., Vanderah, Todd W., Porreca, Frank, Lai, Josephine, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090346/
https://ncbi.nlm.nih.gov/pubmed/21366266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm101023r
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