Deglycosylation and label-free quantitative LC-MALDI MS applied to efficient serum biomarker discovery of lung cancer

BACKGROUND: Serum is an ideal source of biomarker discovery and proteomic profiling studies are continuously pursued on serum samples. However, serum is featured by high level of protein glycosylations that often cause ionization suppression and confound accurate quantification analysis by mass spec...

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Bibliographische Detailangaben
Hauptverfasser: Toyama, Atsuhiko, Nakagawa, Hidewaki, Matsuda, Koichi, Ishikawa, Nobuhisa, Kohno, Nobuoki, Daigo, Yataro, Sato, Taka-Aki, Nakamura, Yusuke, Ueda, Koji
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090313/
https://ncbi.nlm.nih.gov/pubmed/21473792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-5956-9-18
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