Structure of D-AKAP2:PKA RI complex: Insights into AKAP specificity and selectivity

A-kinase anchoring proteins (AKAPs) regulate cyclic AMP-dependent protein kinase (PKA) signaling in space and time. Dual-specific AKAP 2 (D-AKAP2) binds to the dimerization/docking (D/D) domain of both RI and RII regulatory subunits of PKA with high affinity. Here, we have determined the structures...

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Detaylı Bibliyografya
Asıl Yazarlar: Sarma, Ganapathy N., Kinderman, Francis S., Kim, Choel, von Daake, Sventja, Chen, Lirong, Wang, Bi-Cheng, Taylor, Susan S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090270/
https://ncbi.nlm.nih.gov/pubmed/20159461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.12.012
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