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Enantioselective Total Synthesis of (+)-Gliocladine C. A Convergent Construction of Cyclotryptamine-Fused Polyoxopiperazines and a General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors

A concise second-generation total synthesis of the fungal-derived alkaloid (+)-gliocladin C (11), in ten steps and 11% overall yield from isatin, is reported. In addition, the ETP natural product (+)-gliocladine C (6) is prepared in six steps and 29% yield from the di-(tert-butoxycarbonyl) precursor...

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Detalhes bibliográficos
Main Authors: DeLorbe, John E., Jabri, Salman Y., Mennen, Steven M., Overman, Larry E., Zhang, Fang-Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3090078/
https://ncbi.nlm.nih.gov/pubmed/21473649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja201789v
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