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A General Approach for Preparing Epidithiodioxopiperazines from Trioxopiperazine Precursors. Enantioselective Total Syntheses of (+)- and (−)- Gliocladine C, (+)-Leptosin D, (+)-T988C, Bionectin A and (+)-Gliocladin A

A common strategy for preparing tryptophan-derived epidithiodioxopiperazine (ETP) natural product containing a hydroxyl substituent adjacent to a quaternary carbon stereocenter is reported. This strategy is exemplified by enantioselective total syntheses of four heptacyclic ETP natural products — gl...

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Detalhes bibliográficos
Main Authors: DeLorbe, John E., Horne, David, Jove, Richard, Mennen, Steven M., Nam, Sangkil, Zhang, Fang-Li, Overman, Larry E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3640572/
https://ncbi.nlm.nih.gov/pubmed/23452236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400315y
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