Effects of Pluronic and Doxorubicin on Drug Uptake, Cellular Metabolism, Apoptosis and Tumor Inhibition in Animal Models of MDR Cancers

Cancer chemotherapy is believed to be impeded by multidrug resistance (MDR). Pluronic (triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), PEO-b-PPO-b-PEO) were previously shown to sensitize MDR tumors to antineoplastic agents. This study uses animal models of Lewis lu...

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Detalhes bibliográficos
Main Authors: Batrakova, Elena V., Li, Shu, Brynskikh, Anna M., Sharma, Amit K., Li, Yili, Boska, Michael, Gong, Nan, Mosley, R. Lee, Alakhov, Valery Yu., Gendelman, Howard E., Kabanov, Alexander V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089980/
https://ncbi.nlm.nih.gov/pubmed/20074598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2010.01.004
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