The synthetic bryostatin analog Merle 23 dissects distinct mechanisms of bryostatin activity in the LNCaP human prostate cancer cell line

Bryostatin 1 has attracted considerable attention both as a cancer chemotherapeutic agent and for its unique activity. Although it functions, like phorbol esters, as a potent protein kinase C (PKC) activator, it paradoxically antagonizes many phorbol ester responses in cells. Because of its complex...

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Hauptverfasser: Kedei, Noemi, Telek, Andrea, Czap, Alexandra, Lubart, Emanuel S., Czifra, Gabriella, Yang, Dazhi, Chen, Jinqiu, Morrison, Tyler, Goldsmith, Paul K., Lim, Langston, Mannan, Poonam, Garfield, Susan H., Kraft, Matthew B., Li, Wei, Keck, Gary E., Blumberg, Peter M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089703/
https://ncbi.nlm.nih.gov/pubmed/21458422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2011.03.018
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