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Combined anticancer effects of sphingosine kinase inhibitors and sorafenib
The pro-apoptotic lipid sphingosine is phosphorylated by sphingosine kinases 1 and 2 (SK1 and SK2) to generate the mitogenic lipid sphingosine-1-phosphate (S1P). We previously reported that inhibition of SK activity delays tumor growth in a mouse mammary adenocarcinoma model. Because SK inhibitors a...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3089696/ https://ncbi.nlm.nih.gov/pubmed/20473784 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-010-9452-0 |
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