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A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

The Mac-1 integrin is expressed mainly on myeloid cells and binds several ligands, including members of the ICAM family and the complement factor iC3b. It is involved in essential immunological processes, such as leukocyte extravasation and phagocytosis. In addition, Mac-1 has been described to nega...

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書誌詳細
主要な著者: MacPherson, Matthew, Lek, Hwee San, Prescott, Alan, Fagerholm, Susanna C.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089572/
https://ncbi.nlm.nih.gov/pubmed/21454473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182998
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