hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity

hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway. hSSB1 is required for the efficient recruitment of the MRN complex to sites of DSBs and for the efficient initiation o...

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Hlavní autoři: Richard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, White, Malcolm F., Khanna, Kum Kum
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089470/
https://ncbi.nlm.nih.gov/pubmed/21227926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1340
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