Poly(ADP-ribose) polymerase and XPF–ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells

Poly(ADP-Ribose) (PAR) polymerase (PARP) inhibitors represent a promising class of novel anticancer agents. The present study explores the molecular rationale for combining veliparib (ABT-888) with camptothecin (CPT) and its clinical derivatives, topotecan and irinotecan. ABT-888 inhibited PAR induc...

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Autori principali: Zhang, Yong-Wei, Regairaz, Marie, Seiler, Jennifer A., Agama, Keli K., Doroshow, James H., Pommier, Yves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Genome Integrity, Repair and Replication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089458/
https://ncbi.nlm.nih.gov/pubmed/21227924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1304
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