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Modeling Evolutionary Dynamics of Epigenetic Mutations in Hierarchically Organized Tumors

The cancer stem cell (CSC) concept is a highly debated topic in cancer research. While experimental evidence in favor of the cancer stem cell theory is apparently abundant, the results are often criticized as being difficult to interpret. An important reason for this is that most experimental data t...

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Detalhes bibliográficos
Main Authors: Sottoriva, Andrea, Vermeulen, Louis, Tavaré, Simon
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088646/
https://ncbi.nlm.nih.gov/pubmed/21573198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1001132
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