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Aprataxin localizes to mitochondria and preserves mitochondrial function

Ataxia with oculomotor apraxia 1 is caused by mutation in the APTX gene, which encodes the DNA strand-break repair protein aprataxin. Aprataxin exhibits homology to the histidine triad superfamily of nucleotide hydrolases and transferases and removes 5′-adenylate groups from DNA that arise from abor...

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Detalles Bibliográficos
Autores principales: Sykora, Peter, Croteau, Deborah L., Bohr, Vilhelm A., Wilson, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088601/
https://ncbi.nlm.nih.gov/pubmed/21502511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100084108
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