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3-Hydroxykynurenine Suppresses CD4(+) T-Cell Proliferation, Induces T-Regulatory-Cell Development, and Prolongs Corneal Allograft Survival

PURPOSE. IDO (indoleamine 2,3-dioxygenase) modulates the immune response by depletion of the essential amino acid tryptophan, and IDO overexpression has been shown to prolong corneal allograft survival. This study was conducted to examine the effect of kynurenines, the products of tryptophan breakdo...

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Bibliografske podrobnosti
Main Authors: Zaher, Sarah S., Germain, Conrad, Fu, Hongmei, Larkin, Daniel F. P., George, Andrew J. T.
Format: Artigo
Jezik:Inglês
Izdano: Association for Research in Vision and Ophthalmology, Inc. 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088555/
https://ncbi.nlm.nih.gov/pubmed/21212175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-5793
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