Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

We have previously shown that rat allogeneic DC, made immature by adenoviral gene transfer of the dominant negative form of IKK2, gave rise in-vitro to a unique population of CD4(+)CD25(−) regulatory T cells (dnIKK2-Treg). These cells inhibited Tcell response in-vitro, without needing cell-to-cell c...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Aiello, Sistiana, Rocchetta, Federica, Longaretti, Lorena, Faravelli, Silvia, Todeschini, Marta, Cassis, Linda, Pezzuto, Francesca, Tomasoni, Susanna, Azzollini, Nadia, Mister, Marilena, Mele, Caterina, Conti, Sara, Breno, Matteo, Remuzzi, Giuseppe, Noris, Marina, Benigni, Ariela
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599553/
https://ncbi.nlm.nih.gov/pubmed/28912528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08617-3
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