SU11248 (sunitinib) directly inhibits the activity of mammalian 5′-AMP-activated protein kinase (AMPK)

AMPK has been termed the fuel sensor of mammalian cells because it directly responds to the depletion of the fuel molecule ATP. In previous work, we found that AMPK is strongly activated by tumor-like hypoxia and glucose deprivation, independently of the oxygen response system associated with HIF-1....

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Hlavní autoři: Laderoute, Keith R, Calaoagan, Joy M, Madrid, Peter B, Klon, Anthony E, Ehrlich, Paula J
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2010
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087946/
https://ncbi.nlm.nih.gov/pubmed/20495370
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