The rational design of a novel potent analogue of the 5’-AMP-activated protein kinase inhibitor compound C with improved selectivity and cellular activity

We have designed and synthesized analogues of compound C, a non-specific inhibitor of 5’-AMP-activated protein kinase (AMPK), using a computational fragment-based drug design (FBDD) approach. Synthesizing only twenty-seven analogues yielded a compound that was equipotent to compound C in the inhibit...

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Detalhes bibliográficos
Main Authors: Machrouhi, Fouzia, Ouhamou, Nouara, Laderoute, Keith, Calaoagan, Joy, Bukhtiyarova, Marina, Ehrlich, Paula J., Klon, Anthony E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957560/
https://ncbi.nlm.nih.gov/pubmed/20932747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.088
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