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CD46 in innate and adaptive immunity: an update

CD46 was discovered in 1986 during a search for novel C3b-binding proteins. CD46 is expressed ubiquitously and functions as a co-factor in the factor I-mediated proteolytic cleavage of C3b and C4b. Its vital role in preventing complement deposition on host tissue is underpinned by the fact that defi...

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Bibliografiske detaljer
Main Authors: Cardone, J, Le Friec, G, Kemper, C
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087925/
https://ncbi.nlm.nih.gov/pubmed/21488871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2011.04400.x
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