FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

Oncogenic activation of the RAS-ERK MAP kinase signaling pathway can lead to uncontrolled proliferation but can also result in apoptosis or premature cellular senescence, both regarded as natural protective barriers to cell immortalization and transformation. In FGFR3-related skeletal dyplasias, onc...

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Main Authors: Krejci, Pavel, Prochazkova, Jirina, Smutny, Jiri, Chlebova, Katarina, Lin, Patricia, Aklian, Anie, Bryja, Vitezslav, Kozubik, Alois, Wilcox, William R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087869/
https://ncbi.nlm.nih.gov/pubmed/20362703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.03.021
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