NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells

The FGFR3 receptor tyrosine kinase represents an attractive target for therapy due to its role in several human disorders, including skeletal dysplasias, multiple myeloma, and cervical and bladder carcinomas. By using molecular library screening, we identified a compound named NF449 with inhibitory...

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Detalhes bibliográficos
Main Authors: Krejci, Pavel, Murakami, Shunichi, Prochazkova, Jirina, Trantirek, Lukas, Chlebova, Katarina, Ouyang, Zhufeng, Aklian, Anie, Smutny, Jiri, Bryja, Vitezslav, Kozubik, Alois, Wilcox, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898326/
https://ncbi.nlm.nih.gov/pubmed/20439987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083626
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