FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

Oncogenic activation of the RAS-ERK MAP kinase signaling pathway can lead to uncontrolled proliferation but can also result in apoptosis or premature cellular senescence, both regarded as natural protective barriers to cell immortalization and transformation. In FGFR3-related skeletal dyplasias, onc...

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Detalhes bibliográficos
Main Authors: Krejci, Pavel, Prochazkova, Jirina, Smutny, Jiri, Chlebova, Katarina, Lin, Patricia, Aklian, Anie, Bryja, Vitezslav, Kozubik, Alois, Wilcox, William R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087869/
https://ncbi.nlm.nih.gov/pubmed/20362703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2010.03.021
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