Fosmidomycin Uptake into Plasmodium and Babesia-Infected Erythrocytes Is Facilitated by Parasite-Induced New Permeability Pathways

BACKGROUND: Highly charged compounds typically suffer from low membrane permeability and thus are generally regarded as sub-optimal drug candidates. Nonetheless, the highly charged drug fosmidomycin and its more active methyl-derivative FR900098 have proven parasiticidal activity against erythrocyti...

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Detalhes bibliográficos
Main Authors: Baumeister, Stefan, Wiesner, Jochen, Reichenberg, Armin, Hintz, Martin, Bietz, Sven, Harb, Omar S., Roos, David S., Kordes, Maximilian, Friesen, Johannes, Matuschewski, Kai, Lingelbach, Klaus, Jomaa, Hassan, Seeber, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087763/
https://ncbi.nlm.nih.gov/pubmed/21573242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019334
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