Fosmidomycin, a Novel Chemotherapeutic Agent for Malaria

In previous studies, fosmidomycin has been shown to possess activity against Plasmodium falciparum in vitro and in the mouse model. It has a novel mode of action through inhibition of 1-deoxy-d-xylulose 5-phosphate reductoisomerase, an enzyme of the nonmevalonate pathway of isoprenoid biosynthesis,...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Lell, Bertrand, Ruangweerayut, Ronnatrai, Wiesner, Jochen, Missinou, Michel Anoumou, Schindler, Andreas, Baranek, Thomas, Hintz, Martin, Hutchinson, David, Jomaa, Hassan, Kremsner, Peter Gottfried
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2003
Fag:	Clinical Therapeutics
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151759/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12543685/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.47.2.735-738.2003
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