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Normal bone marrow signal-transduction profiles: a requisite for enhanced detection of signaling dysregulations in AML

Molecular and cytogenetic alterations are involved in virtually every facet of acute myeloid leukemia (AML), including dysregulation of major signal-transduction pathways. The present study examines 5 phosphoproteins (pErk, pAkt, pS6, pStat3, and pStat5) in response to 5 cytokine/growth factors (ste...

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Detalhes bibliográficos
Main Authors: Marvin, James, Swaminathan, Suchitra, Kraker, Geoffrey, Chadburn, Amy, Jacobberger, James, Goolsby, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087538/
https://ncbi.nlm.nih.gov/pubmed/21233314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-316026
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