High-resolution kinetics of cytokine signaling in human CD34/CD117-positive cells in unfractionated bone marrow

Cytokine-mediated phosphorylation of Erk (pErk), ribosomal S6 (pS6), and Stat5 (pStat5) in CD34(+)/CD117(+) blast cells in normal bone marrow from 9 healthy adult donors were analyzed over 60 minutes. Treatment with stem cell factor (SCF), Flt3-ligand (FL), IL-3, and GM-CSF and measurement by multip...

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Detalhes bibliográficos
Main Authors: Woost, Philip G., Solchaga, Luis A., Meyerson, Howard J., Shankey, T. Vincent, Goolsby, Charles L., Jacobberger, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087539/
https://ncbi.nlm.nih.gov/pubmed/21330471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-316224
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