Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes

Multiple observations support the existence of developmental differences in megakaryocytopoiesis. We have previously shown that neonatal megakaryocyte (MK) progenitors are hyperproliferative and give rise to MKs smaller and of lower ploidy than adult MKs. Based on these characteristics, neonatal MKs...

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Détails bibliographiques
Auteurs principaux: Liu, Zhi-Jian, Italiano, Joseph, Ferrer-Marin, Francisca, Gutti, Ravi, Bailey, Matthew, Poterjoy, Brandon, Rimsza, Lisa, Sola-Visner, Martha
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Hematopoiesis and Stem Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087534/
https://ncbi.nlm.nih.gov/pubmed/21304100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-293092
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