Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments

The low frequency of hematopoietic stem and progenitor cells (HSPCs) in human BM has precluded analysis of the direct biochemical effects elicited by cytokines in these populations, and their functional consequences. Here, single-cell phospho-specific flow cytometry was used to define the signaling...

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Autores principales: Gibbs, Kenneth D., Gilbert, Penney M., Sachs, Karen, Zhao, Feifei, Blau, Helen M., Weissman, Irving L., Nolan, Garry P., Majeti, Ravindra
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087474/
https://ncbi.nlm.nih.gov/pubmed/21357764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-298232
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