Interruption of intrachromosomal looping by CCCTC binding factor decoy proteins abrogates genomic imprinting of human insulin-like growth factor II

Monoallelic expression of IGF2 is regulated by CCCTC binding factor (CTCF) binding to the imprinting control region (ICR) on the maternal allele, with subsequent formation of an intrachromosomal loop to the promoter region. The N-terminal domain of CTCF interacts with SUZ12, part of the polycomb rep...

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Main Authors: Zhang, He, Niu, Beibei, Hu, Ji-Fan, Ge, Shengfang, Wang, Haibo, Li, Tao, Ling, Jianqun, Steelman, Brandon N., Qian, Guanxiang, Hoffman, Andrew R.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2011
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087012/
https://ncbi.nlm.nih.gov/pubmed/21536749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201101021
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