Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer

PURPOSE: We have evaluated the eukaryotic translation initiation factor 4E (eIF4E) as a potential biomarker and therapeutic target in breast cancer. eIF4E facilitates nuclear export and translation of specific, growth-stimulatory mRNAs and is frequently overexpressed in cancer. EXPERIMENTAL DESIGN:...

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Detalhes bibliográficos
Main Authors: Pettersson, Filippa, Yau, Christina, Dobocan, Monica C, Culjkovic-Kraljacic, Biljana, Retrouvay, Hélène, Puckett, Rachel, Flores, Ludmila M., Krop, Ian E., Rousseau, Caroline, Cocolakis, Eftihia, Borden, Katherine L B, Benz, Christopher C, Miller, Wilson H
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086959/
https://ncbi.nlm.nih.gov/pubmed/21415224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2334
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