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Ribavirin targets eIF4E dependent Akt survival signaling
The eukaryotic translation initiation factor eIF4E is dysregulated in many cancers. eIF4E, through its mRNA export and translation functions, combinatorially modulates the expression of genes involved in Akt dependent survival signaling. For these activities, eIF4E must bind the 7-methyl guanosine (...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2573464/ https://ncbi.nlm.nih.gov/pubmed/18706892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.07.163 |
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