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Global expression profiling reveals gain-of-function onco-genic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis

Thyroid hormone receptors (TRs) are critical in regulating gene expression in normal physiological processes. Decreased expression and/or somatic mutations of TRs have been shown to be associated several types of human cancers including liver, breast, lung, and thyroid. To understand the molecular m...

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Autors principals: Lu, Changxue, Mishra, Alok, Zhu, Yuelin J, Meltzer, Paul, Cheng, Sheue-yann
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086765/
https://ncbi.nlm.nih.gov/pubmed/21547001
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