ROLE OF THE NALP3 INFLAMMASOME IN ACETAMINOPHEN-INDUCED STERILE INFLAMMATION AND LIVER INJURY

Acetaminophen (APAP) overdose is the leading cause of acute liver failure in the US and UK. Recent studies implied that APAP-induced injury is partially mediated by interleukin-1β (IL-1β), which can activate and recruit neutrophils, exacerbating injury. Mature IL-1β is formed by caspase-1, dependent...

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Bibliographische Detailangaben
Hauptverfasser: Williams, C. David, Antoine, Daniel J., Shaw, Patrick J., Benson, Craig, Farhood, Anwar, Williams, Dominic P., Kanneganti, Thirumala-Devi, Park, B. Kevin, Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086334/
https://ncbi.nlm.nih.gov/pubmed/21396389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.03.001
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