Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

Hematopoietic stem cells (HSC) can be harmed by disease, chemotherapy, radiation and normal aging. We now show that damage also occurs in mice repeatedly treated with very low doses of lipopolysaccharide (LPS). Overall health of the animals was good, and there were relatively minor changes in marrow...

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Huvudupphovsmän: Esplin, Brandt L., Shimazu, Tomoyuki, Welner, Robert S., Garrett, Karla P., Nie, Lei, Zhang, Qingzhao, Humphrey, Mary Beth, Yang, Qi, Borghesi, Lisa A., Kincade, Paul W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086167/
https://ncbi.nlm.nih.gov/pubmed/21441445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003438
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