Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR)

Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) regulate xenobiotic sensing and metabolism through interactions with multiple exogenous and endogenous chemicals. Compounds that activate CAR are often ligands of PXR; attention is therefore given to discovery of new, receptor-spec...

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Main Authors: Anderson, Linnea E., Dring, Ann M., Hamel, Laura D., Stoner, Matthew A.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086002/
https://ncbi.nlm.nih.gov/pubmed/21315811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2011.02.004
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