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APOBEC3-Mediated Hypermutation of Retroviral Vectors Produced from Some Retrovirus Packaging Cell Lines
APOBEC3 proteins are packaged into retrovirus virions and can hypermutate retroviruses during reverse transcription. We find that HT-1080 human fibrosarcoma cells hypermutate retroviruses, and that the HT-1080 cell-derived FLYA13 retrovirus packaging cells also hypermutate a retrovirus vector produc...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3085560/ https://ncbi.nlm.nih.gov/pubmed/21209627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.177 |
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