Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells

The transcription factor FOXP3 is essential for the suppressive function of regulatory T cells that are required for maintaining self-tolerance. We have solved the crystal structure of the FOXP3 forkhead domain, as a ternary complex with the DNA-binding domain of nuclear factor of activated T cells-...

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Detalhes bibliográficos
Main Authors: Bandukwala, Hozefa S., Wu, Yongqing, Feurer, Markus, Chen, Yongheng, Barbosa, Bianca, Ghosh, Srimoyee, Stroud, James C., Benoist, Christophe, Mathis, Diane, Rao, Anjana, Chen, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085397/
https://ncbi.nlm.nih.gov/pubmed/21458306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.02.017
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