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Human aging and somatic point mutations in mtDNA: A comparative study of generational differences (grandparents and grandchildren)

The accumulation of somatic mutations in mtDNA is correlated with aging. In this work, we sought to identify somatic mutations in the HVS-1 region (D-loop) of mtDNA that might be associated with aging. For this, we compared 31 grandmothers (mean age: 63 ± 2.3 years) and their 62 grandchildren (mean...

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Detalhes bibliográficos
Main Authors: do Rosário Marinho, Anderson Nonato, de Moraes, Milene Raiol, Santos, Sidney, Ribeiro-dos-Santos, Ândrea
Formato: Artigo
Idioma:Inglês
Publicado em: Sociedade Brasileira de Genética 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3085369/
https://ncbi.nlm.nih.gov/pubmed/21637539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/S1415-47572010005000106
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