Genomic Instability, Defective Spermatogenesis, Immunodeficiency, and Cancer in a Mouse Model of the RIDDLE Syndrome

Eukaryotic cells have evolved to use complex pathways for DNA damage signaling and repair to maintain genomic integrity. RNF168 is a novel E3 ligase that functions downstream of ATM,γ-H2A.X, MDC1, and RNF8. It has been shown to ubiquitylate histone H2A and to facilitate the recruitment of other DNA...

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Detalhes bibliográficos
Main Authors: Bohgaki, Toshiyuki, Bohgaki, Miyuki, Cardoso, Renato, Panier, Stephanie, Zeegers, Dimphy, Li, Li, Stewart, Grant S., Sanchez, Otto, Hande, M. Prakash, Durocher, Daniel, Hakem, Anne, Hakem, Razqallah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084200/
https://ncbi.nlm.nih.gov/pubmed/21552324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1001381
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