PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

Intestinal epithelial cell (IEC) apoptosis contributes to the development of ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects the colon and rectum. Therapies that target the inflammatory cytokine TNF have been found to inhibit IEC apoptosis in patients with IBD, although the...

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Bibliographic Details
Main Authors: Qiu, Wei, Wu, Bin, Wang, Xinwei, Buchanan, Monica E., Regueiro, Miguel D., Hartman, Douglas J., Schoen, Robert E., Yu, Jian, Zhang, Lin
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083802/
https://ncbi.nlm.nih.gov/pubmed/21490394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42917
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