PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice

Intestinal epithelial cell (IEC) apoptosis contributes to the development of ulcerative colitis (UC), an inflammatory bowel disease (IBD) that affects the colon and rectum. Therapies that target the inflammatory cytokine TNF have been found to inhibit IEC apoptosis in patients with IBD, although the...

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Detalhes bibliográficos
Main Authors: Qiu, Wei, Wu, Bin, Wang, Xinwei, Buchanan, Monica E., Regueiro, Miguel D., Hartman, Douglas J., Schoen, Robert E., Yu, Jian, Zhang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083802/
https://ncbi.nlm.nih.gov/pubmed/21490394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42917
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