Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

Disordered glucagon secretion contributes to the symptoms of diabetes, and reduced glucagon action is known to improve glucose homeostasis. In mice, genetic deletion of the glucagon receptor (Gcgr) results in increased levels of the insulinotropic hormone glucagon-like peptide 1 (GLP-1), which may c...

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Bibliographic Details
Main Authors: Ali, Safina, Lamont, Benjamin J., Charron, Maureen J., Drucker, Daniel J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083792/
https://ncbi.nlm.nih.gov/pubmed/21540554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43615
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