Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is closely associated with colon cancer. Expression of the enzyme heparanase is clearly linked to colon carcinoma progression, but its role in UC is unknown. Here we demonstrate for what we believe to be the first time the importan...

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Hauptverfasser: Lerner, Immanuel, Hermano, Esther, Zcharia, Eyal, Rodkin, Dina, Bulvik, Raanan, Doviner, Victoria, Rubinstein, Ariel M., Ishai-Michaeli, Rivka, Atzmon, Ruth, Sherman, Yoav, Meirovitz, Amichay, Peretz, Tamar, Vlodavsky, Israel, Elkin, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083784/
https://ncbi.nlm.nih.gov/pubmed/21490396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43792
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