Lyn and PECAM-1 function as interdependent inhibitors of platelet aggregation

Inhibition of platelet responsiveness is important to control pathologic thrombus formation. Platelet–endothelial cell adhesion molecule-1 (PECAM-1) and the Src family kinase Lyn inhibit platelet activation by the glycoprotein VI (GPVI) collagen receptor; however, it is not known whether PECAM-1 and...

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Main Authors: Ming, Zhangyin, Hu, Yu, Xiang, Jizhou, Polewski, Peter, Newman, Peter J., Newman, Debra K.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Platelets and Thrombopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083302/
https://ncbi.nlm.nih.gov/pubmed/21297004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-304816
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