Keratinocyte Growth Factor Augments Pulmonary Innate Immunity through Epithelium-driven, GM-CSF-dependent Paracrine Activation of Alveolar Macrophages

Keratinocyte growth factor (KGF) is an epithelial mitogen that has been reported to protect the lungs from a variety of insults. In this study, we tested the hypothesis that KGF augments pulmonary host defense. We found that a single dose of intrapulmonary KGF enhanced the clearance of Escherichia c...

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Autores principales: Wu, Huixing, Suzuki, Takuji, Carey, Brenna, Trapnell, Bruce C., McCormack, Francis X.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Immunology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083236/
https://ncbi.nlm.nih.gov/pubmed/21343299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.182170
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