The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1

Dnmt1 (DNA methyltransferase 1) is the principal enzyme responsible for maintenance of cytosine methylation at CpG dinucleotides in the mammalian genome. The N-terminal replication focus targeting sequence (RFTS) domain of Dnmt1 has been implicated in subcellular localization, protein association, a...

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Detalhes bibliográficos
Main Authors: Syeda, Farisa, Fagan, Rebecca L., Wean, Matthew, Avvakumov, George V., Walker, John R., Xue, Sheng, Dhe-Paganon, Sirano, Brenner, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083197/
https://ncbi.nlm.nih.gov/pubmed/21389349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209882
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