Lowering Glycosphingolipid Levels in CD4(+) T Cells Attenuates T Cell Receptor Signaling, Cytokine Production, and Differentiation to the Th(17) Lineage

Lipid rafts reportedly have a role in coalescing key signaling molecules into the immunological synapse during T cell activation, thereby modulating T cell receptor (TCR) signaling activity. Recent findings suggest that a correlation may exist between increased levels of glycosphingolipids (GSLs) in...

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Hlavní autoři: Zhu, Yunxiang, Gumlaw, Nathan, Karman, Jozsef, Zhao, Hongmei, Zhang, Jinhua, Jiang, Ji-Lei, Maniatis, Pete, Edling, Andrea, Chuang, Wei-Lien, Siegel, Craig, Shayman, James A., Kaplan, Johanne, Jiang, Canwen, Cheng, Seng H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083190/
https://ncbi.nlm.nih.gov/pubmed/21402703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.218610
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